Differentiating inflamed and normal lungs by the apparent reaction rate constants of lactate dehydrogenase probed by hyperpolarized (13)C labeled pyruvate

BACKGROUND: Clinically translatable hyperpolarized (HP) (13)C-NMR can probe in vivo enzymatic reactions, e.g., lactate dehydrogenase (LDH)-catalyzed reaction by injecting HP (13)C-pyruvate into the subject, which is converted to (13)C labeled lactate by the enzyme. Parameters such as (13)C-lactate s...

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Veröffentlicht in:Quant Imaging Med Surg
Hauptverfasser: Xu, He N., Kadlececk, Stephen, Shaghaghi, Hoora, Zhao, Huaqing, Profka, Harilla, Pourfathi, Mehrdad, Rizi, Rahim, Li, Lin Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: AME Publishing Company 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775246/
https://ncbi.nlm.nih.gov/pubmed/26981456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2223-4292.2016.02.04
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