Effects of UCP4 on the Proliferation and Apoptosis of Chondrocytes: Its Possible Involvement and Regulation in Osteoarthritis

Reactive oxygen species (ROS)-induced chondrocytes apoptosis plays a key role in osteoarthritis (OA) pathogenesis. Uncoupling protein 4 (UCP4) can protect cells against oxidative stress via reducing ROS production and cell apoptosis. Here, silencing of UCP4 in primary chondrocytes significantly inhi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Huang, Zhongming, Li, Junhua, Du, Shaohua, Chen, Guangnan, Qi, Yiying, Huang, Ligang, Xiao, Luwei, Tong, Peijian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775028/
https://ncbi.nlm.nih.gov/pubmed/26934480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150684
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