Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

In 2010 the identities of thousands of anti-Plasmodium compounds were released publicly to facilitate malaria drug development. Understanding these compounds’ mechanisms of action—i.e., the specific molecular targets by which they kill the parasite—would further facilitate the drug development proce...

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Publicat a:PLoS One
Autors principals: Crowther, Gregory J., Hillesland, Heidi K., Keyloun, Katelyn R., Reid, Molly C., Lafuente-Monasterio, Maria Jose, Ghidelli-Disse, Sonja, Leonard, Stephen E., He, Panqing, Jones, Jackson C., Krahn, Mallory M., Mo, Jack S., Dasari, Kartheek S., Fox, Anna M. W., Boesche, Markus, El Bakkouri, Majida, Rivas, Kasey L., Leroy, Didier, Hui, Raymond, Drewes, Gerard, Maly, Dustin J., Van Voorhis, Wesley C., Ojo, Kayode K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774911/
https://ncbi.nlm.nih.gov/pubmed/26934697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149996
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