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Cyclophilin A (CypA) Plays Dual Roles in Regulation of Bone Anabolism and Resorption

CypA (Cyclophilin A) is a peptidyl-prolyl isomerase previously shown to be required for chondrogenic differentiation and endochondral ossification. However, the effects of CypA on osteoclast activity and bone maintenance are entirely unknown. Here, we show that Ppia(−/−) mice demonstrate low bone mi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Principais autores: Guo, Mian, James, Aaron W., Kwak, Jin Hee, Shen, Jia, Yokoyama, Kazunari K., Ting, Kang, Soo, Chia B., Chiu, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774113/
https://ncbi.nlm.nih.gov/pubmed/26932182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22378
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