Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

Naive CD4+ T cells produce interleukin 2 (IL-2) but little IL-4 or interferon gamma (IFN-gamma). In vitro, they develop into IL-4 or IFN-gamma producers depending on the conditions of the priming culture. Using T-cell receptor transgenic CD4+ T cells, the role of IL-12 and IL-4 in antigen-specific p...

Full description

Saved in:
Bibliographic Details
Main Authors: Seder, R A, Gazzinelli, R, Sher, A, Paul, W E
Format: Artigo
Language:Inglês
Published: 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC47739/
https://ncbi.nlm.nih.gov/pubmed/7901851
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items