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Eliminating medullary 5-HT neurons delays arousal and decreases the respiratory response to repeated episodes of hypoxia in neonatal rat pups

Arousal from sleep is a critical defense mechanism when infants are exposed to hypoxia, and an arousal deficit has been postulated as contributing to the etiology of the sudden infant death syndrome (SIDS). The brainstems of SIDS infants are deficient in serotonin (5-HT) and tryptophan hydroxylase (...

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Publicat a:J Appl Physiol (1985)
Autors principals: Darnall, Robert A., Schneider, Robert W., Tobia, Christine M., Commons, Kathryn G.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773643/
https://ncbi.nlm.nih.gov/pubmed/26702023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00560.2014
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