Population physiologically-based pharmacokinetic model incorporating lymphatic uptake for a subcutaneously administered pegylated peptide

PURPOSE: Physiologically-based pharmacokinetic (PBPK) models provide a rational mechanistic approach for predicting the time course of macromolecules in plasma. Population PBPK models for large molecules necessitate incorporation of lymphatic circulation to mechanistically account for biodistributio...

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Bibliografische gegevens
Gepubliceerd in:In Silico Pharmacol
Hoofdauteurs: Offman, Elliot, Phipps, Colin, Edginton, Andrea N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Berlin Heidelberg 2016
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773320/
https://ncbi.nlm.nih.gov/pubmed/26932471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40203-016-0018-5
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