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Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

BACKGROUND: Ebola virus disease (EVD) is a highly lethal condition for which no specific treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak, the World Health Organization released a short list of drugs suitable for EVD research. Favipiravir, an antiviral devel...

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Detalhes bibliográficos
Publicado no:PLoS Med
Main Authors: Sissoko, Daouda, Laouenan, Cedric, Folkesson, Elin, M’Lebing, Abdoul-Bing, Beavogui, Abdoul-Habib, Baize, Sylvain, Camara, Alseny-Modet, Maes, Piet, Shepherd, Susan, Danel, Christine, Carazo, Sara, Conde, Mamoudou N., Gala, Jean-Luc, Colin, Géraldine, Savini, Hélène, Bore, Joseph Akoi, Le Marcis, Frederic, Koundouno, Fara Raymond, Petitjean, Frédéric, Lamah, Marie-Claire, Diederich, Sandra, Tounkara, Alexis, Poelart, Geertrui, Berbain, Emmanuel, Dindart, Jean-Michel, Duraffour, Sophie, Lefevre, Annabelle, Leno, Tamba, Peyrouset, Olivier, Irenge, Léonid, Bangoura, N’Famara, Palich, Romain, Hinzmann, Julia, Kraus, Annette, Barry, Thierno Sadou, Berette, Sakoba, Bongono, André, Camara, Mohamed Seto, Chanfreau Munoz, Valérie, Doumbouya, Lanciné, Souley Harouna, Kighoma, Patient Mumbere, Koundouno, Fara Roger, Réné Lolamou, Loua, Cécé Moriba, Massala, Vincent, Moumouni, Kinda, Provost, Célia, Samake, Nenefing, Sekou, Conde, Soumah, Abdoulaye, Arnould, Isabelle, Komano, Michel Saa, Gustin, Lina, Berutto, Carlotta, Camara, Diarra, Camara, Fodé Saydou, Colpaert, Joliene, Delamou, Léontine, Jansson, Lena, Kourouma, Etienne, Loua, Maurice, Malme, Kristian, Manfrin, Emma, Maomou, André, Milinouno, Adele, Ombelet, Sien, Sidiboun, Aboubacar Youla, Verreckt, Isabelle, Yombouno, Pauline, Bocquin, Anne, Carbonnelle, Caroline, Carmoi, Thierry, Frange, Pierre, Mely, Stéphane, Nguyen, Vinh-Kim, Pannetier, Delphine, Taburet, Anne-Marie, Treluyer, Jean-Marc, Kolie, Jacques, Moh, Raoul, Gonzalez, Minerva Cervantes, Kuisma, Eeva, Liedigk, Britta, Ngabo, Didier, Rudolf, Martin, Thom, Ruth, Kerber, Romy, Gabriel, Martin, Di Caro, Antonino, Wölfel, Roman, Badir, Jamal, Bentahir, Mostafa, Deccache, Yann, Dumont, Catherine, Durant, Jean-François, El Bakkouri, Karim, Gasasira Uwamahoro, Marie, Smits, Benjamin, Toufik, Nora, Van Cauwenberghe, Stéphane, Ezzedine, Khaled, Dortenzio, Eric, Pizarro, Louis, Etienne, Aurélie, Guedj, Jérémie, Fizet, Alexandra, Barte de Sainte Fare, Eric, Murgue, Bernadette, Tran-Minh, Tuan, Rapp, Christophe, Piguet, Pascal, Poncin, Marc, Draguez, Bertrand, Allaford Duverger, Thierry, Barbe, Solenne, Baret, Guillaume, Defourny, Isabelle, Carroll, Miles, Raoul, Hervé, Augier, Augustin, Eholie, Serge P., Yazdanpanah, Yazdan, Levy-Marchal, Claire, Antierrens, Annick, Van Herp, Michel, Günther, Stephan, de Lamballerie, Xavier, Keïta, Sakoba, Mentre, France, Anglaret, Xavier, Malvy, Denis
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773183/
https://ncbi.nlm.nih.gov/pubmed/26930627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1001967
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