Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity

Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Stasiak, Marta, Boncela, Joanna, Perreau, Corinne, Karamanou, Konstantina, Chatron-Colliet, Aurore, Proult, Isabelle, Przygodzka, Patrycja, Chakravarti, Shukti, Maquart, François-Xavier, Kowalska, M. Anna, Wegrowski, Yanusz, Brézillon, Stéphane
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773148/
https://ncbi.nlm.nih.gov/pubmed/26930497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150226
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