Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity

BACKGROUND: Recent studies have linked certain single nucleotide polymorphisms in the leucine-rich repeat kinase 2 (LRRK2) gene with Parkinson’s disease (PD). Among the mutations, LRRK2 c.4883G>C (R1628P) variant was identified to have a significant association with the risk of PD in ethnic Han-C...

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Udgivet i:PLoS One
Main Authors: Shu, Yang, Ming, Jie, Zhang, Pei, Wang, Qingzhi, Jiao, Fengjuan, Tian, Bo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773127/
https://ncbi.nlm.nih.gov/pubmed/26930193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149739
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