Comparison of Monovalent Glycoprotein B with Bivalent gB/pp65 (GP83) Vaccine for Congenital Cytomegalovirus Infection in a Guinea Pig Model: Inclusion of GP83 Reduces Antibody Response but Provides Equivalent Protection Against Mortality

Cytomegalovirus (CMV) subunit vaccine candidates include glycoprotein B (gB), and phosphoprotein ppUL83 (pp65). Using a guinea pig cytomegalovirus (GPCMV) model, this study compared immunogenicity, pregnancy outcome, and congenital viral infection following pre-pregnancy immunization with a three-do...

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Опубликовано в: :Vaccine
Главные авторы: Swanson, Elizabeth C., Gillis, Pete, Hernandez-Alvarado, Nelmary, Fernández-Alarcón, Claudia, Schmit, Megan, Zabeli, Jason C., Wussow, Felix, Diamond, Don J., Schleiss, Mark R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772145/
https://ncbi.nlm.nih.gov/pubmed/26079615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2015.06.019
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