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Molecular characterization of HIV-1 Nef and ACOT8 interaction: insights from in silico structural predictions and in vitro functional assays

HIV-1 Nef interacts with several cellular proteins, among which the human peroxisomal thioesterase 8 (ACOT8). This interaction may be involved in the endocytosis regulation of membrane proteins and might modulate lipid composition in membrane rafts. Nef regions involved in the interaction have been...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Serena, Michela, Giorgetti, Alejandro, Busato, Mirko, Gasparini, Francesca, Diani, Erica, Romanelli, Maria Grazia, Zipeto, Donato
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772117/
https://ncbi.nlm.nih.gov/pubmed/26927806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22319
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