Intestinal Epithelial Toll-Like Receptor 4 Signaling Affects Epithelial Function and Colonic Microbiota and Promotes a Risk for Transmissible Colitis

Evidence obtained from gene knockout studies supports the role of Toll-like receptor 4 (TLR4) in intestinal inflammation and microbiota recognition. Increased epithelial TLR4 expression is observed in patients with inflammatory bowel disease. However, little is known of the effect of increased TLR4...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Dheer, Rishu, Santaolalla, Rebeca, Davies, Julie M., Lang, Jessica K., Phillips, Matthew C., Pastorini, Cristhine, Vazquez-Pertejo, Maria T., Abreu, Maria T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Host Response and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771346/
https://ncbi.nlm.nih.gov/pubmed/26755160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01374-15
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