SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane

Overexpression of SPARC, a collagen-binding glycoprotein, is strongly associated with tumor invasion through extracellular matrix in many aggressive cancers. SPARC regulates numerous cellular processes including integrin-mediated cell adhesion, cell signaling pathways, and extracellular matrix assem...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Morrissey, Meghan A., Jayadev, Ranjay, Miley, Ginger R., Blebea, Catherine A., Chi, Qiuyi, Ihara, Shinji, Sherwood, David R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771172/
https://ncbi.nlm.nih.gov/pubmed/26926673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005905
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