Quantitative Measurement of Cationic Polymer Vector and Polymer/pDNA Polyplex Intercalation into the Cell Plasma Membrane

Cationic gene delivery agents (vectors) are important for delivering nucleotides, but are also responsible for cytotoxicity. Cationic polymers (L-PEI, jetPEI, and G5 PAMAM) at 1x to 100x the concentrations required for translational activity (protein expression) induced the same increase in plasma m...

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Udgivet i:ACS Nano
Main Authors: Vaidyanathan, Sriram, Anderson, Kevin B., Merzel, Rachel L., Jacobovitz, Binyamin, Kaushik, Milan P., Kelly, Christina N., van Dongen, Mallory A., Dougherty, Casey A., Orr, Bradford G., Holl, Mark M. Banaszak
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771022/
https://ncbi.nlm.nih.gov/pubmed/25952271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.5b01263
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