Prognostic impact of mismatch repair genes germline defects in colorectal cancer patients: are all mutations equal?

BACKGROUND: Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome, caused by germline mutations in MisMatch Repair (MMR) genes, particularly in MLH1, MSH2 and MSH6. Patients with LS seem to have a more favourable prognosis than those with sporadic CRC, although the progn...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Maccaroni, Elena, Bracci, Raffaella, Giampieri, Riccardo, Bianchi, Francesca, Belvederesi, Laura, Brugiati, Cristiana, Pagliaretta, Silvia, Del Prete, Michela, Scartozzi, Mario, Cascinu, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770733/
https://ncbi.nlm.nih.gov/pubmed/26485756
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