Prognostic impact of mismatch repair genes germline defects in colorectal cancer patients: are all mutations equal?

BACKGROUND: Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome, caused by germline mutations in MisMatch Repair (MMR) genes, particularly in MLH1, MSH2 and MSH6. Patients with LS seem to have a more favourable prognosis than those with sporadic CRC, although the progn...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Maccaroni, Elena, Bracci, Raffaella, Giampieri, Riccardo, Bianchi, Francesca, Belvederesi, Laura, Brugiati, Cristiana, Pagliaretta, Silvia, Del Prete, Michela, Scartozzi, Mario, Cascinu, Stefano
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770733/
https://ncbi.nlm.nih.gov/pubmed/26485756
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