Relationship of urinary endothelin-1 with estimated glomerular filtration rate in autosomal dominant polycystic kidney disease: a pilot cross-sectional analysis

BACKGROUND: The pathogenesis of progressive renal insufficiency in autosomal dominant polycystic kidney disease (ADPKD) is unclear. Evidence from experimental models of ADPKD suggests that elevated endothelin-1 (ET-1) drives cyst growth, renal fibrosis and loss of renal function, but whether ET-1 is...

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Detalhes bibliográficos
Publicado no:BMC Nephrol
Main Authors: Raina, Rupesh, Lou, Linda, Berger, Bruce, Vogt, Beth, Do, Angelique Sao-Mai, Cunningham, Robert, Vasavada, Pauravi, Herrmann, Karin, Dell, Katherine, Simonson, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770683/
https://ncbi.nlm.nih.gov/pubmed/26923419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12882-016-0232-8
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