Screening for major driver oncogene alterations in adenosquamous lung carcinoma using PCR coupled with next-generation and Sanger sequencing methods

We investigated the frequency of major driver oncogenes in lung adenosquamous cell carcinoma (ASC) cases. Frequency of EGFR, K-Ras, B-Raf, PIK3CA, DDR2, ALK, and PDGFRA gene mutations was examined in 56 patients using next-generation sequencing, polymerase chain reaction, and Sanger sequencing. Macr...

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Vydáno v:Sci Rep
Hlavní autoři: Shi, Xiaohua, Wu, Huanwen, Lu, Junliang, Duan, Huanli, Liu, Xuguang, Liang, Zhiyong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770439/
https://ncbi.nlm.nih.gov/pubmed/26923333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22297
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