Antibody-dependent enhancement of dengue virus infection inhibits RLR-mediated Type-I IFN-independent signalling through upregulation of cellular autophagy

Antibody dependent enhancement (ADE) of dengue virus (DENV) infection is identified as the main risk factor of severe Dengue diseases. Through opsonization by subneutralizing or non-neutralizing antibodies, DENV infection suppresses innate cell immunity to facilitate viral replication. However, it i...

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Vydáno v:Sci Rep
Hlavní autoři: Huang, Xinwei, Yue, Yaofei, Li, Duo, Zhao, Yujiao, Qiu, Lijuan, Chen, Junying, Pan, Yue, Xi, Juemin, Wang, Xiaodan, Sun, Qiangming, Li, Qihan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770412/
https://ncbi.nlm.nih.gov/pubmed/26923481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22303
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