Ferredoxin 1b (Fdx1b) Is the Essential Mitochondrial Redox Partner for Cortisol Biosynthesis in Zebrafish

Mitochondrial cytochrome P450 (CYP) enzymes rely on electron transfer from the redox partner ferredoxin 1 (FDX1) for catalytic activity. Key steps in steroidogenesis require mitochondrial CYP enzymes and FDX1. Over 30 ferredoxin mutations have been explored in vitro; however, no spontaneously occurr...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Griffin, Aliesha, Parajes, Silvia, Weger, Meltem, Zaucker, Andreas, Taylor, Angela E., O'Neil, Donna M., Müller, Ferenc, Krone, Nils
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769370/
https://ncbi.nlm.nih.gov/pubmed/26650568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1480
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