FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice

β-Cell compensation is an essential mechanism by which β-cells increase insulin secretion for overcoming insulin resistance to maintain euglycemia in obesity. Failure of β-cells to compensate for insulin resistance contributes to insulin insufficiency and overt diabetes. To understand the mechanism...

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Veröffentlicht in:Endocrinology
Hauptverfasser: Zhang, Ting, Kim, Dae Hyun, Xiao, Xiangwei, Lee, Sojin, Gong, Zhenwei, Muzumdar, Radhika, Calabuig-Navarro, Virtu, Yamauchi, Jun, Harashima, Hideyoshi, Wang, Rennian, Bottino, Rita, Alvarez-Perez, Juan Carlos, Garcia-Ocaña, Adolfo, Gittes, George, Dong, H. Henry
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2016
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769368/
https://ncbi.nlm.nih.gov/pubmed/26727107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1852
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