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Low-Dose IL-17 Therapy Prevents and Reverses Diabetic Nephropathy, Metabolic Syndrome, and Associated Organ Fibrosis

Diabetes is the leading cause of kidney failure, accounting for >45% of new cases of dialysis. Diabetic nephropathy is characterized by inflammation, fibrosis, and oxidant stress, pathologic features that are shared by many other chronic inflammatory diseases. The cytokine IL-17A was initially im...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Mohamed, Riyaz, Jayakumar, Calpurnia, Chen, Feng, Fulton, David, Stepp, David, Gansevoort, Ron T., Ramesh, Ganesan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769194/
https://ncbi.nlm.nih.gov/pubmed/26334030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014111136
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