Umbilical cord blood–derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

We studied the safety and clinical outcomes of patients treated with umbilical cord blood (UCB)-derived regulatory T cells (Tregs) that expanded in cultures stimulated with K562 cells modified to express the high-affinity Fc receptor (CD64) and CD86, the natural ligand of CD28 (KT64/86). Eleven pati...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Brunstein, Claudio G., Miller, Jeffrey S., McKenna, David H., Hippen, Keli L., DeFor, Todd E., Sumstad, Darin, Curtsinger, Julie, Verneris, Michael R., MacMillan, Margaret L., Levine, Bruce L., Riley, James L., June, Carl H., Le, Chap, Weisdorf, Daniel J., McGlave, Philip B., Blazar, Bruce R., Wagner, John E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2016
Schlagworte:
Transplantation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768428/
https://ncbi.nlm.nih.gov/pubmed/26563133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-653667
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