Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration

PURPOSE: nab-paclitaxel demonstrates improved clinical efficacy compared with conventional Cremophor EL (CrEL)-paclitaxel in multiple tumor types. This study explored the distinctions in drug distribution between nab-paclitaxel and CrEL-paclitaxel and the underlying mechanisms. METHODS: Uptake and t...

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Vydáno v:Cancer Chemother Pharmacol
Hlavní autoři: Chen, Nianhang, Brachmann, Carrie, Liu, Xiping, Pierce, Daniel W., Dey, Joyoti, Kerwin, William S., Li, Yan, Zhou, Simon, Hou, Shihe, Carleton, Michael, Klinghoffer, Richard A., Palmisano, Maria, Chopra, Rajesh
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768222/
https://ncbi.nlm.nih.gov/pubmed/26231955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2833-5
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