Integrative studies of scleroderma-associated genetic and environmental factors with fibroblasts identify polymorphisms of TNFAIP3 in association with MMP expression

OBJECTIVES: Systemic Sclerosis (SSc) is a fibrotic disease attributed to both genetic susceptibility and environmental factors. Our studies tried to demonstrate how human fibroblasts with SSc associated genetic variants respond to time-course and dose-response expression of the extracellular matrix...

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Veröffentlicht in:Arthritis Rheumatol
Hauptverfasser: Wei, Peng, Yang, Yang, Guo, Xinjian, Hei, Nainan, Lai, Syeling, Assassi, Shervin, Liu, Mengyuan, Tan, Filemon, Zhou, Xiaodong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767670/
https://ncbi.nlm.nih.gov/pubmed/26474180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39476
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