Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via TGF-β Signaling

OBJECTIVE: Collagen accumulation and calcification are major determinants of atherosclerotic plaque stability. Extracellular vesicle (EV)-derived microcalcifications in the collagen-poor fibrous cap may promote plaque rupture. In this study, we hypothesize that the collagen receptor discoidin domain...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Krohn, Jona B., Hutcheson, Joshua D., Martínez-Martínez, Eduardo, Irvin, Whitney S., Bouten, Carlijn V.C., Bertazzo, Sergio, Bendeck, Michelle P., Aikawa, Elena
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767541/
https://ncbi.nlm.nih.gov/pubmed/26800565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.307009
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