Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis

Podoplanin (PDPN) enhances tumor metastases by eliciting tumor cell-induced platelet aggregation (TCIPA) through activation of platelet C-type lectin-like receptor 2 (CLEC-2). A novel and non-cytotoxic 5-nitrobenzoate compound 2CP was synthesized that specifically inhibited the PDPN/CLEC-2 interacti...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Chang, Yao-Wen, Hsieh, Pei-Wen, Chang, Yu-Tsui, Lu, Meng-Hong, Huang, Tur-Fu, Chong, Kowit-Yu, Liao, Hsiang-Ruei, Cheng, Ju-Chien, Tseng, Ching-Ping
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767466/
https://ncbi.nlm.nih.gov/pubmed/26528756
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