Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism

To further the development of a model for simultaneously assessing intestinal absorption and first-pass metabolism in vitro, Caco-2, LS180, T84, and fetal human small intestinal epithelial cells (fSIECs) were cultured on permeable inserts, and the integrity of cell monolayers, CYP3A4 activity, and t...

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Xehetasun bibliografikoak
Argitaratua izan da:Drug Metab Dispos
Egile Nagusiak: Yamaura, Yoshiyuki, Chapron, Brian D., Wang, Zhican, Himmelfarb, Jonathan, Thummel, Kenneth E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2016
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767385/
https://ncbi.nlm.nih.gov/pubmed/26700954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.068429
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