Mutations in TUBB8 cause human oocyte meiotic arrest

BACKGROUND: Successful human reproduction depends on the fusion of a mature oocyte with a sperm cell to form a fertilized egg. The genetic events that lead to human oocyte maturation arrest are unknown. METHODS: We recruited a rare four-generation family with female infertility as a consequence of o...

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Gepubliceerd in:N Engl J Med
Hoofdauteurs: Feng, Ruizhi, Sang, Qing, Kuang, Yanping, Sun, Xiaoxi, Yan, Zheng, Zhang, Shaozhen, Shi, Juanzi, Tian, Guoling, Luchniak, Anna, Fukuda, Yusuke, Li, Bin, Yu, Min, Chen, Junling, Xu, Yao, Guo, Luo, Qu, Ronggui, Wang, Xueqian, Sun, Zhaogui, Liu, Miao, Shi, Huijuan, Wang, Hongyan, Feng, Yi, Shao, Ruijin, Chai, Renjie, Li, Qiaoli, Xing, Qinghe, Zhang, Rui, Nogales, Eva, Jin, Li, He, Lin, Gupta, Mohan L., Cowan, Nicholas J., Wang, Lei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767273/
https://ncbi.nlm.nih.gov/pubmed/26789871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1510791
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