IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis

OBJECTIVES: Indoleamine 2,3-dioxygenase-1 (IDO1) is an immune-modulatory enzyme that catalyzes the degradation of tryptophan (Trp) to kynurenine (Kyn) and is strongly induced by interferon (IFN)-γ. We previously reported highly increased levels of IFN-γ and corresponding IDO activity in patients wit...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Put, Karen, Brisse, Ellen, Avau, Anneleen, Imbrechts, Maya, Mitera, Tania, Janssens, Rik, Proost, Paul, Fallarino, Francesca, Wouters, Carine H., Matthys, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767214/
https://ncbi.nlm.nih.gov/pubmed/26914138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150075
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