Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.
As the action of aldose reductase (EC 1.1.1.21) is believed to be linked to the pathogenesis of diabetic complications affecting the nervous, renal, and visual systems, the development of therapeutic agents has attracted intense effort. We report the refined 1.8 A x-ray structure of the human holoen...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8234324/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.21.9847 |
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