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Light-controlled cellular internalization and cytotoxicity of nucleic acid-binding agents. Studies in vitro and in zebrafish embryos

We have synthesized oligoarginine conjugates of selected DNA-binding agents (a bisbenzamidine, acridine and thiazole orange) and demonstrated that the DNA binding and cell internalization properties of such conjugates can be inhibited by appending a negatively charged oligoglutamic tail through a ph...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Penas, Cristina, Sánchez, Mateo I., Guerra-Varela, Jorge, Sanchez-Piñón, Laura, Vázquez, M. Eugenio, Mascareñas, José L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766732/
https://ncbi.nlm.nih.gov/pubmed/26534774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500455
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