Development of an Ointment Formulation Using Hot-Melt Extrusion Technology

Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and...

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Détails bibliographiques
Publié dans:AAPS PharmSciTech
Auteurs principaux: Bhagurkar, Ajinkya M., Angamuthu, Muralikrishnan, Patil, Hemlata, Tiwari, Roshan V., Maurya, Abhijeet, Hashemnejad, Seyed Meysam, Kundu, Santanu, Murthy, S. Narasimha, Repka, Michael A.
Format: Artigo
Langue:Inglês
Publié: Springer US 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766123/
https://ncbi.nlm.nih.gov/pubmed/26628438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-015-0453-3
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