SIRT3-AMPK Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)

BACKGROUND: Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) is an increasingly recognized clinical complication of metabolic syndrome. No adequate animal model of PH-HFpEF is available and no effective therapies have been identified to date. A recent...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Lai, Yen-Chun, Tabima, Diana M., Dube, John J., Hughan, Kara S., Vanderpool, Rebecca R., Goncharov, Dmitry A., St Croix, Claudette M., Garcia-Ocaña, Adolfo, Goncharova, Elena A., Tofovic, Stevan P., Mora, Ana L., Gladwin, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766041/
https://ncbi.nlm.nih.gov/pubmed/26813102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.018935
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