Efficacy and harms of direct oral anticoagulants in the elderly for stroke prevention in atrial fibrillation and secondary prevention of venous thromboembolism: systematic review and meta-analysis

BACKGROUND: Evidence regarding use of direct oral anticoagulants (DOACs) in the elderly, particularly bleeding risks, is unclear despite the presence of greater comorbidities, polypharmacy and altered pharmacokinetics in this age group. METHODS AND RESULTS: We performed a systematic review and meta-...

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Vydáno v:Circulation
Hlavní autoři: Sharma, Manuj, Cornelius, Victoria R, Patel, Jignesh P, Davies, J Graham, Molokhia, Mariam
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765082/
https://ncbi.nlm.nih.gov/pubmed/25995317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.114.013267
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