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Impaired theta-gamma coupling in APP-deficient mice

Amyloid precursor protein (APP) is critically involved in the pathophysiology of Alzheimer’s disease, but its physiological functions remain elusive. Importantly, APP knockout (APP-KO) mice exhibit cognitive deficits, suggesting that APP plays a role at the neuronal network level. To investigate thi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Zhang, Xiaomin, Zhong, Wewei, Brankačk, Jurij, Weyer, Sascha W., Müller, Ulrike C., Tort, Adriano B. L., Draguhn, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764939/
https://ncbi.nlm.nih.gov/pubmed/26905287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21948
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