The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

Increasing incidence of inflammatory bowel disorders demands a better understanding of the molecular mechanisms underlying its multifactorial aetiology. Here we demonstrate that mice deficient for REGγ, a proteasome activator, show significantly attenuated intestinal inflammation and colitis-associa...

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Publicado no:Nat Commun
Main Authors: Xu, Jinjin, Zhou, Lei, Ji, Lei, Chen, Fengyuan, Fortmann, Karen, Zhang, Kun, Liu, Qingwu, Li, Ke, Wang, Weicang, Wang, Hao, Xie, Wei, Wang, Qingwei, Liu, Jiang, Zheng, Biao, Zhang, Pei, Huang, Shixia, Shi, Tieliu, Zhang, Biaohong, Dang, Yongyan, Chen, Jiwu, O'Malley, Bert W., Moses, Robb E., Wang, Ping, Li, Lei, Xiao, Jianru, Hoffmann, Alexander, Li, Xiaotao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764899/
https://ncbi.nlm.nih.gov/pubmed/26899380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10761
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