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Mutant p53 in concert with an IL27 Receptor α deficiency causes spontaneous liver inflammation, fibrosis, and steatosis
BACKGROUND: The cellular and molecular etiology of unresolved chronic liver inflammation remains obscure. While mutant p53 has gain-of-function properties in tumors, the role of this protein in liver inflammation is unknown. MAIN: Herein, mutant p53(R172H) is mechanistically linked to spontaneous an...
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| Publicado no: | Hepatology |
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| Principais autores: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4764463/ https://ncbi.nlm.nih.gov/pubmed/26637970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28379 |
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