Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats

Reduced peripheral serotonin (5HT) in mice lacking tryptophan hydroxylase (TPH1), the rate limiting enzyme for 5HT synthesis, was reported to be anabolic to the skeleton. However, in other studies TPH1 deletion either had no bone effect or an age dependent inhibition of osteoclastic bone resorption....

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Erjavec, Igor, Bordukalo-Niksic, Tatjana, Brkljacic, Jelena, Grcevic, Danka, Mokrovic, Gordana, Kesic, Maja, Rogic, Dunja, Zavadoski, William, Paralkar, Vishwas M., Grgurevic, Lovorka, Trkulja, Vladimir, Cicin-Sain, Lipa, Vukicevic, Slobodan
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764355/
https://ncbi.nlm.nih.gov/pubmed/26907598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150102
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