TNFα mediates stress-induced depression by upregulating indoleamine 2,3-dioxygenase in a mouse model of unpredictable chronic mild stress

Depression is often preceded by exposure to stressful life events. Chronic stress causes perturbations in the immune system, and up-regulates production of proinflammatory cytokines, which has been proposed to be associated with the pathogenesis of clinical depression. However, the potential mechani...

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Veröffentlicht in:Eur Cytokine Netw
Hauptverfasser: Liu, Yu-Ning, Peng, Yun-Li, Lei-Liu, Wu, Teng-Yun, Zhang, Yi, Lian, Yong-Jie, Yang, Yuan-Yuan, Kelley, Keith W, Jiang, Chun-Lei, Wang, Yun-Xia
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764086/
https://ncbi.nlm.nih.gov/pubmed/26083579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1684/ecn.2015.0362
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