Poor repair of skeletal muscle in aging mice reflects a defect in local, interleukin-33-dependent, accumulation of regulatory T cells

Normal repair of skeletal muscle requires local expansion of a special population of Foxp3(+)CD4(+) regulatory T (Treg) cells. Such cells failed to accumulate in acutely injured muscle of old mice, known to undergo ineffectual repair. This defect reflected reduced recruitment of Treg cells to injure...

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Udgivet i:Immunity
Main Authors: Kuswanto, Wilson, Burzyn, Dalia, Panduro, Marisella, Wang, Kathy K., Jang, Young Charles, Wagers, Amy J., Benoist, Christophe, Mathis, Diane
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764071/
https://ncbi.nlm.nih.gov/pubmed/26872699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.01.009
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