Ambient glucose and aldose reductase-induced myo-inositol depletion modulate basal and carbachol-stimulated inositol phospholipid metabolism and diacylglycerol accumulation in human retinal pigment epithelial cells in culture.

Physiological hyperglycemia has been speculated to alter phosphoinositide (PPI; inositol phospholipid) signal transduction in cells prone to diabetic complications by two separate mass-action mechanisms with antiparallel putative effects on diacylglycerol (DAG): (i) sorbitol-induced depletion of myo...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Thomas, T P, Feldman, E L, Nakamura, J, Kato, K, Lien, M, Stevens, M J, Greene, D A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47640/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8415767/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.20.9712
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!