T cell-specific inactivation of mouse CD2 by CRISPR/Cas9

The CRISPR/Cas9 system can be used to mutate target sequences by introduction of double-strand breaks followed by imprecise repair. To test its use for conditional gene editing we generated mice transgenic for CD4 promoter-driven Cas9 combined with guide RNA targeting CD2. We found that within CD4(+...

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Publicado no:Sci Rep
Main Authors: Beil-Wagner, Jane, Dössinger, Georg, Schober, Kilian, vom Berg, Johannes, Tresch, Achim, Grandl, Martina, Palle, Pushpalatha, Mair, Florian, Gerhard, Markus, Becher, Burkhard, Busch, Dirk H., Buch, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763270/
https://ncbi.nlm.nih.gov/pubmed/26903281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21377
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