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Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis

Clozapine is the only evidence-based therapy for treatment-resistant schizophrenia, but it induces agranulocytosis, a rare but potentially fatal haematological adverse reaction, in less than 1% of users. To improve safety, the drug is subject to mandatory haematological monitoring throughout the cou...

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Detalhes bibliográficos
Publicado no:Pharmacogenomics J
Main Authors: Verbelen, M, Collier, D A, Cohen, D, MacCabe, J H, Lewis, C M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762904/
https://ncbi.nlm.nih.gov/pubmed/25732907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2015.5
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