JPH-2 INTERACTS WITH Ca(i)-HANDLING PROTEINS AND ION CHANNELS IN DYADS: CONTRIBUTION TO PREMATURE VENTRICULAR CONTRACTION-INDUCED CARDIOMYOPATHY

BACKGROUND: In a canine model of premature ventricular contraction-induced cardiomyopathy (PVC-CM), Cav1.2 is downregulated and misplaced from t-tubules. Junctophilin-2 (JPH-2) is also downregulated. OBJECTIVE: To understand the role of JPH-2 in PVC-CM, and to probe changes in other proteins involve...

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Veröffentlicht in:Heart Rhythm
Hauptverfasser: Jiang, Min, Zhang, Mei, Howren, Maureen, Wang, Yuhong, Tan, Alex, Balijepalli, Ravi C., Huizar, Jose F., Tseng, Gea-Ny
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762763/
https://ncbi.nlm.nih.gov/pubmed/26538326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2015.10.037
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