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Bipartite recognition of target RNAs activates DNA cleavage by the Type III-B CRISPR–Cas system
CRISPR–Cas systems eliminate nucleic acid invaders in bacteria and archaea. The effector complex of the Type III-B Cmr system cleaves invader RNAs recognized by the CRISPR RNA (crRNA ) of the complex. Here we show that invader RNAs also activate the Cmr complex to cleave DNA. As has been observed fo...
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| Publicado no: | Genes Dev |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4762429/ https://ncbi.nlm.nih.gov/pubmed/26848045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.272153.115 |
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