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Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells
Podophyllotoxin (PT) and its clinically used analogues are known to be powerful antitumour agents. These compounds contain a trans fused strained γ-lactone system, a feature that correlates to the process of epimerisation, whereby the trans γ-lactone system of ring D opens and converts to the more t...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Eur J Med Chem |
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| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Editions Scientifiques Elsevier
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4762250/ https://ncbi.nlm.nih.gov/pubmed/26854430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.12.037 |
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