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Main path and byways: non-vesicular glutamate release by system x(c)(−) as an important modifier of glutamatergic neurotransmission

System x(c)(−) is a cystine/glutamate antiporter that exchanges extracellular cystine for intracellular glutamate. Cystine is intracellularly reduced to cysteine, a building block of GSH. As such, system x(c)(−) can regulate the antioxidant capacity of cells. Moreover, in several brain regions, syst...

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Detalhes bibliográficos
Publicado no:J Neurochem
Main Authors: Massie, Ann, Boillee, Severine, Hewett, Sandra, Knackstedt, Lori, Lewerenz, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762049/
https://ncbi.nlm.nih.gov/pubmed/26336934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13348
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