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NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators
Heterodimers of CLOCK and BMAL1 are the major transcriptional activators of the mammalian circadian clock. Because the paralog NPAS2 can substitute for CLOCK in the suprachiasmatic nucleus (SCN), the master circadian pacemaker, CLOCK-deficient mice maintain circadian rhythms in behavior and in tissu...
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| Pubblicato in: | PLoS Genet |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4760943/ https://ncbi.nlm.nih.gov/pubmed/26895328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005882 |
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