Growth hormone receptor antagonist (GHA) transgenic mice have increased subcutaneous adipose tissue mass, altered glucose homeostasis, and no change in white adipose tissue cellular senescence

BACKGROUND: Growth hormone (GH) resistant/deficient mice experience improved glucose homeostasis and substantially increased lifespan. Recent evidence suggests long-lived GH resistant/deficient mice are protected from white adipose tissue (WAT) dysfunction, including WAT cellular senescence, impaire...

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Published in:Gerontology
Main Authors: Comisford, Ross, Lubbers, Ellen R., Householder, Lara, Suer, Ozan, Tchkonia, Tamara, Kirkland, James L., List, Edward O., Kopchick, John J., Berryman, Darlene E.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760896/
https://ncbi.nlm.nih.gov/pubmed/26372907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000439050
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